Prodrome | Frequently Asked Questions

ProdromeNeuro™ and ProdromeGlia™ are both dietary supplements that are synthetically pure, vegan plasmalogen precursors. The difference between the two lies in their fatty acid composition and targeted area of effect within the body.

ProdromeNeuro™ is an omega-3 (DHA) plasmalogen precursor that targets gray matter in the brain. DHA is extracted and purified from plant-based triglycerides and attached to a plasmalogen precursor backbone. This process makes ProdromeNeuro™ bioidentical to naturally occurring DHA plasmalogen precursors; however, there are no natural vegetarian sources that offer sufficient purity or concentration for practical use. DHA plasmalogens are found in high concentrations in the membranes of gray matter and are necessary for neuron and neuromuscular synaptic function. They are also involved in reverse cholesterol transport and maintaining low brain amyloid levels.

 ProdromeGlia™ is an omega-9 (oleic acid) plasmalogen precursor that targets white matter in the brain. Like ProdromeNeuro™, it is bioidentical to naturally occurring oleic acid plasmalogen precursors but cannot be practically derived from natural vegetarian sources. The oleic acid used to make ProdromeGlia™ is extracted and purified from plant-based triglycerides. White matter is largely made up of myelin, which requires high levels of omega-9 plasmalogens to function.

Both plasmalogen precursors are manufactured in a cGMP facility in Temecula, CA, USA

To help you choose between ProdromeNeuro™ and ProdromeGlia™, consider the following:

Your age: Plasmalogen levels naturally decline after the age of 50. ProdromeNeuro™ and ProdromeGlia™ can help support cellular health, protect against oxidative stress, and ensure proper cell membrane function.

Your cognitive health: People with dementia experience a rapid decline in plasmalogens, particularly omega-3 plasmalogens. If you are concerned about cognitive decline, you may want to consider ProdromeNeuro™.

Your overall health: White matter degeneration can affect many neurological functions, including movement, sensation, and thinking. If you are concerned about the health of your myelin and white matter, you may want to consider ProdromeGlia™.

Evaluating Your Needs

It is important to note that plasmalogen deficiencies may vary from person to person. We recommend taking the ProdromeScan™ blood test, developed by Dr. Goodenowe, to measure your plasmalogen levels. This test can help you to determine which type of plasmalogen precursor would be most beneficial for you. You can find more information about the ProdromeScan™ here.

While we recommend taking the blood test, it is not required when trying Prodrome plasmalogen products.  Many people take ProdromeNeuro™ in the morning because it has a slightly stimulating effect and ProdromeGlia™ in the evening because it has a calming effect. 

It is essential to consult with a healthcare professional to determine the best course of action for your individual needs. They can help you evaluate your health history and make recommendations based on your specific circumstances. Find a Prodrome practitioner here. 

Other plasmalogen products available are typically derived from animal sources and contain very low concentrations of plasmalogens. For example, one product provides just 0.5mg of plasmalogen per capsule (30mg per bottle), while another contains 4mg per capsule (240mg per bottle). In contrast, Prodrome Plasmalogen products offers a significantly higher concentration, with 900mg of plasmalogens per serving and 27,000mg per bottle—delivering more in a single serving than other products offer in an entire bottle.

Additionally, our ProdromeNeuro™ and ProdromeGlia™ products are plasmalogen precursors, specifically formulated by Dr. Goodenowe for optimal absorption and bioavailability. These precursors are designed to bypass gut degradation, allowing them to quickly and effectively restore plasmalogen levels in the body.

You can take ProdromeNeuro and ProdromeGlia at any time of day. They can be taken with or without food. They can be taken with any other supplements.

However, many prefer taking ProdromeNeuro in the morning and ProdromeGlia in the evening.

The recommended dose is 900mg each day. Some individuals prefer taking a loading dose of 2-4x the daily dose for 1 to 3 months. It is recommended to continue taking the plasmalogen supplement every day. Always consult your healthcare provider to determine what is best for you.

Yes, if you prefer to mix with food you can. 

Yes, you can mix with a hot beverage.

Yes, we test our products using a third-party lab.

The ProdromeNeuro soft gels and ProdromeGlia softgels, as well as ProdromeGlia plasmalogen liquid oil can be stored at room temperature, in a cool, dry place both before and after opening.

Store ProdromeNeuro plasmalogen liquid oil in the refrigerator when you receive it and after opening to maintain freshness. ProdromeNeuro can be kept at room temperature, but we recommend to store in the fridge for freshness. All other supplements can be stored in a cool, dry place.

ProdromeNeuro plasmalogen oil has a shelf life of 18 months prior to opening (once opened it is best to use within 30 days). ProdromeGlia plasmalogen oil has a shelf life of 24 months (once opened it is best to use within 90 days). The ProdromeNeuro and ProdromeGlia softgels have a shelf life of 24 months.

All of the oils have a manufacturing date printed on the bottle and this should not be confused with an expiration date.

Always check the product packaging for the most up to date information.

Always refer to the product listings for the most up to date information. Our plasmalogen oil supplements are vegan, however the softgels are not vegan as the soft gel capsule is made with gelatin. They are not certified non-GMO but the ingredients are all non-GMO. They are not certified organic.

ProdromeNeuro Oil may have a "fishy" smell or taste due to the Omega-3, which is sourced from purified algae.

ProdromeNeuro softgels should be stored at room temperature in a cool, dry place. It is fine to store them in the fridge or freezer for long term storage, but it is not necessary.

ProdromeNeuro plasmalogen liquid oil should be stored in the refrigerator when received and after opening to preserve freshness. The cold chain does not have to be maintained strictly and can be transported at room temperature.